Dendritic phospholipid-based drug delivery systems

Lei Jiang; Weizhi Chen; Sensen Zhou; Cheng Li; Xiaoke Zhang; Wei Wu; Xiqun Jiang

doi:10.1039/C7BM01001J

Dendritic phospholipid-based drug delivery systems†

Lei Jiang,

‡^ab Weizhi Chen,‡^a Sensen Zhou,^a Cheng Li,^a Xiaoke Zhang,^a Wei Wu

*^a and Xiqun Jiang

*^a

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of High Performance Polymer Materials and Technology, and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing, P. R. China
E-mail: jiangx@nju.edu.cn, weiwu@nju.edu.cn

^b State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China

Abstract

A class of new dendritic phospholipid compounds with different hydrophilic dendritic poly(L-lysine) peripheries from generations 1 (G1) to 3 (G3) (DPL-1 to DPL-3) were synthesised and nano-drug delivery systems based on these compounds were prepared (DPN-2 and DPN-3). DPL-1 couldn't self-assemble into nanocarriers. The size, TEM image, and the CD spectrum of DPN-2 and DPN-3 were experimentally examined. The effect of the peripheral structure of dendritic phospholipid-based nanocarriers on their biological performance and drug delivery efficiency was studied. In vitro cytotoxicity studies demonstrated that the DOX-loaded DPN-3 shows higher cytotoxicity against 4T1 cells and BGC823 cells than DPN-2. DOX-loaded DPN-3 also showed excellent behaviours in cell internalization and 4T1 multicellular spheroid penetration. The composition of the hydrophilic block in dendritic phospholipids affected the self-assembly behaviour, properties and delivery efficiency of the formed nanocarriers. This work will be helpful for building drug delivery systems with characteristics of high delivery efficiency and low cytotoxicity for clinical applications.

This article is part of the themed collection: Nanobiointerfaces

Supplementary files

Article information

DOI: https://doi.org/10.1039/C7BM01001J
Article type: Paper
Submitted: 01 Nov 2017
Accepted: 15 Jan 2018
First published: 16 Jan 2018

Download Citation

Biomater. Sci., 2018,6, 774-778

Permissions

Request permissions

Dendritic phospholipid-based drug delivery systems

L. Jiang, W. Chen, S. Zhou, C. Li, X. Zhang, W. Wu and X. Jiang, Biomater. Sci., 2018, 6, 774 DOI: 10.1039/C7BM01001J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Biomaterials Science

Dendritic phospholipid-based drug delivery systems†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Dendritic phospholipid-based drug delivery systems

Social activity

Search articles by author

Spotlight

Advertisements