Issue 10, 2017, Issue in Progress
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RSC Advances

‘Aggregation induced emission’ active iridium(iii) complexes with applications in mitochondrial staining†

Parvej Alam,a   Subhra Dash,b   Claudia Climent,c   Gurpreet Kaur,d   Angshuman Roy Choudhury,d   David Casanova,e   Pere Alemany,c   Rajdeep Chowdhury*b  and  Inamur Rahaman Laskar*a  

* Corresponding authors

a Department of Chemistry, Birla Institute of Technology and Science, Pilani Campus, Pilani, Rajasthan, India
E-mail: ir_laskar@bits-pilani.ac.in

b Department of Biology, Birla Institute of Technology and Science, Pilani Campus, Pilani, Rajasthan, India
E-mail: rajdeep.chowdhury@pilani.bits-pilani.ac.in

c Departament de Ciència de Materials i Química Física and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1-11, Barcelona 08028, Spain
E-mail: p.alemany@ub.edu

d Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER), Sector 81, S. A. S. Nagar, Manauli PO, Mohali, Punjab, India
E-mail: angshurc@iisermohali.ac.in

e Kimika Fakultatea, Euskal Herriko Unibertsitatea (UPV/EHU), Donostia International Physics Center, Paseo Manuel de Lardiazabal, 4, Donostia 20018, Euskadi, Spain

Abstract

Two new bis-cyclometalated iridium(III) complexes, [Ir(F2ppy)2(L)] and [Ir(ppy)2(L)], where F2ppy = 2-(2′,4′-difluoro)phenylpyridine, ppy = 2-phenylpyridine and L = 1,2-((pyridin-2-ylimino)methyl)phenol, have been designed and synthesized by a convenient route. We have univocally characterized their structure by 1H NMR, 19F NMR, HRMS and SXRD. Both complexes exhibit strong ‘Aggregation Induced Emission (AIE)’ activity, which has been investigated using spectroscopy measurements, ab initio quantum chemical calculations and by analysing their crystal packing. One of the complexes has been shown to have a potential application as a non-toxic bio-imaging probe for mitochondrial staining.

Graphical abstract: ‘Aggregation induced emission’ active iridium(iii) complexes with applications in mitochondrial staining

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Article information

DOI
https://doi.org/10.1039/C6RA24792J
Article type
Paper
Submitted
06 Oct 2016
Accepted
01 Dec 2016
First published
17 Jan 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 5642-5648

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‘Aggregation induced emission’ active iridium(III) complexes with applications in mitochondrial staining

P. Alam, S. Dash, C. Climent, G. Kaur, A. R. Choudhury, D. Casanova, P. Alemany, R. Chowdhury and I. R. Laskar, RSC Adv., 2017, 7, 5642 DOI: 10.1039/C6RA24792J

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