Issue 112, 2016, Issue in Progress

In vivo target bio-imaging of cerebral ischemic stroke by real-time labeling of zinc

Abstract

Stroke is a sudden onset disease of the human brain, which has become the second-leading global cause of death after ischemic heart disease. Nowadays, it is especially important to find a rapid, simple, non-toxic targeted imaging reagent. In this contribution we have exploited the potential of zinc gluconate as a novel diagnostic reagent for cerebral ischemic stroke. Our observations demonstrate that zinc ions can readily cross the blood brain barrier in ionic form and assemble under the ischemic and hypoxic condition of stroke supported by inflammation, and in situ biosynthesize fluorescent zinc nanoclusters. This may provide a new strategy for the diagnosis of cerebral ischemic stroke through in vivo fluorescence bioimaging after further investigation.

Graphical abstract: In vivo target bio-imaging of cerebral ischemic stroke by real-time labeling of zinc

Supplementary files

Article information

Article type
Paper
Submitted
21 Sep 2016
Accepted
12 Nov 2016
First published
15 Nov 2016

RSC Adv., 2016,6, 110525-110534

In vivo target bio-imaging of cerebral ischemic stroke by real-time labeling of zinc

C. Zhao, L. Lai, F. U. Rehman, C. Qian, G. Teng, H. Jiang and X. Wang, RSC Adv., 2016, 6, 110525 DOI: 10.1039/C6RA23507G

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