Issue 68, 2016, Issue in Progress
From the journal:

RSC Advances

Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem†

Shucheng Wang,‡a   Xuhu Huang,‡a   Zemei Ge,a   Xin Wang*a  and  Runtao Li*a  

* Corresponding authors

a State Key Laboratory of National and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100191, P. R. China
E-mail: xinwang@bjmu.edu.cn, lirt@bjmu.edu.cn
Fax: +86 10 82805954
Tel: +86 82805954

Abstract

A metal-free process for the C-3 alkylation of imidazopyridines has been developed. Various alkylation products including alkyl ester-, cyano-, ketone- and amide-substituted imidazopyridines were prepared in good yields. With this method, a highly efficient and concise formal synthesis of alpidem (A) and zolpidem (B) has been completed.

Graphical abstract: Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6RA09046J
Article type
Communication
Submitted
08 Apr 2016
Accepted
24 Jun 2016
First published
28 Jun 2016

RSC Adv., 2016,6, 63532-63535

Permissions

Request permissions

Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem

S. Wang, X. Huang, Z. Ge, X. Wang and R. Li, RSC Adv., 2016, 6, 63532 DOI: 10.1039/C6RA09046J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements