Issue 45, 2016, Issue in Progress
From the journal:

RSC Advances

A practical green chemistry approach to synthesize fused bicyclic 4H-pyranes via an amine catalysed 1,4-addition and cyclization cascade†

Jun-Long Li,a   Qiang Li,*a   Kai-Chuan Yang,ac   Yi Li,a   Liang Zhou,a   Bo Han,b   Cheng Peng*b  and  Xiao-Jun Gou*a  

* Corresponding authors

a Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610052, PR China
E-mail: liqiang@cdu.edu.cn, gouxj@163.com

b State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
E-mail: pengcheng@cdutcm.edu.cn

c Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China

Abstract

A newly developed synthetic approach to densely functionalized 4H-pyrane derivatives via an amine catalysed cascade reaction is presented. This protocol is relatively environmentally benign because it proceeds smoothly in water or ethanol at ambient temperature with low catalyst loading; more importantly, the products are easily purified, and some show promising antibacterial activity.

Graphical abstract: A practical green chemistry approach to synthesize fused bicyclic 4H-pyranes via an amine catalysed 1,4-addition and cyclization cascade

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Article information

DOI
https://doi.org/10.1039/C6RA06441H
Article type
Communication
Submitted
10 Mar 2016
Accepted
11 Apr 2016
First published
12 Apr 2016

RSC Adv., 2016,6, 38875-38879

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A practical green chemistry approach to synthesize fused bicyclic 4H-pyranes via an amine catalysed 1,4-addition and cyclization cascade

J. Li, Q. Li, K. Yang, Y. Li, L. Zhou, B. Han, C. Peng and X. Gou, RSC Adv., 2016, 6, 38875 DOI: 10.1039/C6RA06441H

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