Issue 42, 2016, Issue in Progress
From the journal:

RSC Advances

Formation of molecular hydrogels from a bile acid derivative and selected carboxylic acids†

Meng Zhang,a   Karen C. Waldrona  and  X. X. Zhu*a  

* Corresponding authors

a Département de Chimie, Université de Montréal, C.P. 6128, Succ. Centre-ville, Montreal, QC, Canada
E-mail: julian.zhu@umontreal.ca

Abstract

Bile acids are natural compounds that can be made into dimers by covalently linking two of them through diethylenetriamine. A cholic acid dimer of this kind is synthesized and is found to form thermally reversible hydrogels with selected carboxylic acids through combined hydrogen bonding and ionic interactions. The gelation and viscoelastic properties of the hydrogels may be varied by judicious choice of the carboxylic mono- and diacids. The total organic content (the dimer and carboxylic acid) represents about 2% or less by weight in the ternary mixture. The molecular arrangement between the dimer and carboxylic acid is proposed to illustrate the formation mechanism of the hydrogels. The marginal solubility of the dimer–acid mixtures seems to be the deciding factor in obtaining the hydrogels.

Graphical abstract: Formation of molecular hydrogels from a bile acid derivative and selected carboxylic acids

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Article information

DOI
https://doi.org/10.1039/C6RA04536G
Article type
Communication
Submitted
20 Feb 2016
Accepted
31 Mar 2016
First published
04 Apr 2016

RSC Adv., 2016,6, 35436-35440

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Formation of molecular hydrogels from a bile acid derivative and selected carboxylic acids

M. Zhang, K. C. Waldron and X. X. Zhu, RSC Adv., 2016, 6, 35436 DOI: 10.1039/C6RA04536G

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