Issue 35, 2016

Copper-catalyzed enantioselective C–H functionalization of indoles with an axially chiral bipyridine ligand

Abstract

Using copper complexes with an axially chiral bipyridine ligand C4-ACBP as the catalyst, an enantioselective functionalization of indoles with diazo compounds was developed with up to 95% ee. This protocol paves the way for further applications of these ligands.

Graphical abstract: Copper-catalyzed enantioselective C–H functionalization of indoles with an axially chiral bipyridine ligand

Supplementary files

Article information

Article type
Communication
Submitted
16 Jul 2016
Accepted
04 Aug 2016
First published
04 Aug 2016

Org. Biomol. Chem., 2016,14, 8237-8240

Copper-catalyzed enantioselective C–H functionalization of indoles with an axially chiral bipyridine ligand

X. Gao, B. Wu, Z. Yan and Y. Zhou, Org. Biomol. Chem., 2016, 14, 8237 DOI: 10.1039/C6OB01516F

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