Issue 4, 2017

Action-FRET of β-cyclodextrin inclusion complexes

Abstract

Cyclodextrin is commonly used in the formation of supramolecular complexes with an array of targets ranging from metal ion sensing to modulation of peptide properties. Many of the applications of these supramolecular complexes are measured by monitoring the modulation of the optical properties of a chromophore upon formation or breaking of the complex. The transposition of these complexes to the gas phase allows their study in a size selected manner, based on the isolation of specific stoichiometries to be analyzed independently. Förster Resonance Energy Transfer (FRET) is used to study the structure of these supramolecular complexes in solution phase. This motivates the use of action-FRET – a recently developed gas-phase extension of the FRET technique – to study the structure of gaseous supramolecular complexes. Here, the feasibility of performing action-FRET on a supramolecular assembly constituted by a chromophore tagged cyclodextrin receptor and a donor chromophore tagged amyloid beta peptide fragment is considered.

Graphical abstract: Action-FRET of β-cyclodextrin inclusion complexes

Supplementary files

Article information

Article type
Paper
Submitted
17 Oct 2016
Accepted
23 Jan 2017
First published
23 Jan 2017

New J. Chem., 2017,41, 1806-1812

Action-FRET of β-cyclodextrin inclusion complexes

Q. Duez, G. Knight, S. Daly, J. De Winter, E. Halin, L. MacAleese, R. Antoine, P. Gerbaux and P. Dugourd, New J. Chem., 2017, 41, 1806 DOI: 10.1039/C6NJ03250H

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