Cross-triggered and cascaded recycling amplification for ultrasensitive electrochemical sensing of the mutant human p53 gene

Cuiyun Yang; Baoting Dou; Jianmei Yang; Ruo Yuan; Yun Xiang

doi:10.1039/C6CC04587A

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Cross-triggered and cascaded recycling amplification for ultrasensitive electrochemical sensing of the mutant human p53 gene†

Cuiyun Yang,^a Baoting Dou,^a Jianmei Yang,^a Ruo Yuan^a and Yun Xiang*^a

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* Corresponding authors

^a Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
E-mail: yunatswu@swu.edu.cn
Tel: +86-23-68252277

Abstract

Based on an endonuclease-assisted, cross-triggered and cascaded recycling amplification strategy, the construction of a simple electrochemical sensing platform for the ultrasensitive detection of the mutant p53 gene in human serum is described. Using this new signal amplification approach, the sub-femtomolar level of the mutant p53 gene can be selectively detected.

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Article information

DOI: https://doi.org/10.1039/C6CC04587A
Article type: Communication
Submitted: 01 Jun 2016
Accepted: 14 Jun 2016
First published: 15 Jun 2016

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Chem. Commun., 2016,52, 8707-8710

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Cross-triggered and cascaded recycling amplification for ultrasensitive electrochemical sensing of the mutant human p53 gene

C. Yang, B. Dou, J. Yang, R. Yuan and Y. Xiang, Chem. Commun., 2016, 52, 8707 DOI: 10.1039/C6CC04587A

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Chemical Communications

Cross-triggered and cascaded recycling amplification for ultrasensitive electrochemical sensing of the mutant human p53 gene†

Abstract

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Cross-triggered and cascaded recycling amplification for ultrasensitive electrochemical sensing of the mutant human p53 gene

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