Issue 34, 2015
From the journal:

RSC Advances

Cytotoxic saponin poliusaposide from Teucrium polium†

Wael A. Elmasri,a   Mohamed-Elamir F. Hegazy,b   Yehia Mechrefa  and  Paul W. Paré*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, USA
E-mail: Paul.Pare@ttu.edu
Fax: +1 806 742 1289

b Chemistry of Medicinal Plants Department, Center of Excellence for Advanced Sciences, National Research Centre, Giza, Egypt

Abstract

Three saponin glycosides have been isolated and characterized from Teucrium polium L. (Lamiaceae). The compounds were isolated from a MeOH aerial plant extract. The structures were elucidated based on spectroscopic methods including UV, IR, 1D and 2D NMR, and HRESIMS data analyses. The identified compounds were evaluated for anticancer effects against 60 human tumor cell lines (NCI). The triterpene glycoside, poliusaposide C completely inhibited the growth of a breast and colon cancer cell line and partially inhibited the growth of a colon, renal and melanoma cell line. Structure–anticancer activity relationships are discussed.

Graphical abstract: Cytotoxic saponin poliusaposide from Teucrium polium

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Article information

DOI
https://doi.org/10.1039/C5RA02713F
Article type
Paper
Submitted
11 Feb 2015
Accepted
11 Mar 2015
First published
17 Mar 2015

RSC Adv., 2015,5, 27126-27133

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Cytotoxic saponin poliusaposide from Teucrium polium

W. A. Elmasri, M. F. Hegazy, Y. Mechref and P. W. Paré, RSC Adv., 2015, 5, 27126 DOI: 10.1039/C5RA02713F

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