An up-converting HAP@β-TCP nanocomposite activated with Er3+/Yb3+ ion pairs for bio-related applications
Abstract
A HAP@β-TCP nanocomposite doped with Er3+/Yb3+ ion pairs was prepared using Pechini’s technique. The structural properties and morphology of the particles were studied by means of XRD, TEM, and DLS techniques. The cytotoxicity of the developed product was tested on canine osteosarcoma (D17) and murine macrophage (J774.E) cells. Determination of metronidazole release from the HAP@β-TCP nanocomposite was carried out using dynamic dialysis and ultracentrifugation techniques. Thorough analysis of the up-conversion properties of the prepared system was carried out, showing that the GRR depends strongly on the sample temperature induced by the optical density of excitation, and the particle size. Relatively short decay times and the behaviour of the GRR pointed towards the enhanced contribution of non-radiative processes feeding the red emission.
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