Issue 13, 2016

Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity

Abstract

Two series of ferrocenyl- and aryl-derived cyclopalladated organosilane thiosemicarbazone complexes were synthesised via C–H bond activation. Selected compounds were evaluated for in vitro antiplasmodial activity against the chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) strains of the human malaria parasite Plasmodium falciparum. Cyclopalladation of the thiosemicarbazones resulted in antiplasmodial activities in the low micromolar range.

Graphical abstract: Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity

Article information

Article type
Paper
Submitted
17 Dec 2015
Accepted
16 Feb 2016
First published
25 Feb 2016
This article is Open Access
Creative Commons BY-NC license

Dalton Trans., 2016,45, 5514-5520

Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity

M. Adams, L. Barnard, C. de Kock, P. J. Smith, L. Wiesner, K. Chibale and G. S. Smith, Dalton Trans., 2016, 45, 5514 DOI: 10.1039/C5DT04918K

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