Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents

Miao Jin; Dominic E. M. Spillane; Carlos F. G. C. Geraldes; Gareth R. Williams; S. W. Annie Bligh

doi:10.1039/C5DT03433G

Gd(iii) complexes intercalated into hydroxy double salts as potential MRI contrast agents†

Miao Jin,^a Dominic E. M. Spillane,^b Carlos F. G. C. Geraldes,^c Gareth R. Williams*^a and S. W. Annie Bligh*^d

* Corresponding authors

^a UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, UK
E-mail: g.williams@ucl.ac.uk

^b School of Human Sciences, London Metropolitan University, 166-220 Holloway Road, London, UK

^c Department of Life Sciences and Coimbra Chemistry Centre, Faculty of Science and Technology, University of Coimbra, Coimbra, Portugal

^d Faculty of Science and Technology, University of Westminster, 115 New Cavendish Street, London, UK
E-mail: a.bligh@westminster.ac.uk

Abstract

The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd³⁺ diethylenetriaminepentaacetate and Gd³⁺ diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5–18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd³⁺ complexes in the intercalation compounds. The proton relaxivities of the Gd³⁺ complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents.

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DOI: https://doi.org/10.1039/C5DT03433G
Article type: Paper
Submitted: 03 Sep 2015
Accepted: 30 Oct 2015
First published: 04 Nov 2015

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Dalton Trans., 2015,44, 20728-20734

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Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents

M. Jin, D. E. M. Spillane, C. F. G. C. Geraldes, G. R. Williams and S. W. A. Bligh, Dalton Trans., 2015, 44, 20728 DOI: 10.1039/C5DT03433G

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Gd(iii) complexes intercalated into hydroxy double salts as potential MRI contrast agents†

Abstract

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Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents

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