Issue 95, 2015
From the journal:

Chemical Communications

Label-free detection of pH based on the i-motif using an aggregation-caused quenching strategy†

Boshi Fu,a   Jinguo Huang,a   Dongsheng Bai,a   Yalun Xie,a   Yang Wang,a   Shaoru Wang*a  and  Xiang Zhou*a  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Institute of Advanced Studies - 68756663, China
E-mail: xzhou@whu.edu.cn
Tel: +86-27-68756663

Abstract

A label-free and biocompatible pH sensor system based on the aggregation-caused quenching (ACQ) probe has been reported herein. The DNA i-motif, a kind of pH-triggered structure, affects the aggregation of PTCDI derivatives by structural switch that would provide significant fluorescence signals responding to the different pH values. Our method not only shows sensitive and reversible response to pH changes, but also could expand the detection range by allosteric control of the DNA i-motif.

Graphical abstract: Label-free detection of pH based on the i-motif using an aggregation-caused quenching strategy

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Article information

DOI
https://doi.org/10.1039/C5CC04784F
Article type
Communication
Submitted
16 Aug 2015
Accepted
21 Sep 2015
First published
24 Sep 2015

Chem. Commun., 2015,51, 16960-16963

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Label-free detection of pH based on the i-motif using an aggregation-caused quenching strategy

B. Fu, J. Huang, D. Bai, Y. Xie, Y. Wang, S. Wang and X. Zhou, Chem. Commun., 2015, 51, 16960 DOI: 10.1039/C5CC04784F

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