Issue 54, 2015
From the journal:

Chemical Communications

Cationic star copolymers based on β-cyclodextrins for efficient gene delivery to mouse embryonic stem cell colonies†

Xian Jun Loh*abc  and  Yun-Long Wud  

* Corresponding authors

a Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Singapore
E-mail: lohxj@imre.a-star.edu.sg

b Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore

c Singapore Eye Research Institute, 11 Third Hospital Avenue, Singapore 168751, Singapore

d School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, P. R. China

Abstract

A cationic star copolymer with a β-cyclodextrin core was developed for nonviral gene transfer to mouse embryonic stem cells (mESCs). The copolymer comprises poly(2-dimethyl aminoethyl methacrylate) as the cationic component and poly(2-hydroxyethyl methacrylate) as the non-toxic stealth component. These materials have very low toxicity and show highly efficient transfection to mESC colonies.

Graphical abstract: Cationic star copolymers based on β-cyclodextrins for efficient gene delivery to mouse embryonic stem cell colonies

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Article information

DOI
https://doi.org/10.1039/C5CC03686K
Article type
Communication
Submitted
06 May 2015
Accepted
21 May 2015
First published
21 May 2015

Chem. Commun., 2015,51, 10815-10818

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Cationic star copolymers based on β-cyclodextrins for efficient gene delivery to mouse embryonic stem cell colonies

X. J. Loh and Y. Wu, Chem. Commun., 2015, 51, 10815 DOI: 10.1039/C5CC03686K

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