We report a new MCR involving the reaction of isatoic anhydrides, allyl amine and o-bromo arylaldehydes in the presence of Pd(OAc)2, X-Phos and air to afford various isoquinolino[1,2-b]quinazolinones as new cytotoxic agents. The strategy was extended successfully towards the synthesis of a methyl analogue of 7,8-dehydrorutaecarpine.
R. Adepu, B. Prasad, M. A. Ashfaq, N. Z. Ehtesham and M. Pal, RSC Adv., 2014, 4, 49324 DOI: 10.1039/C4RA10702K
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