Issue 105, 2014
From the journal:

RSC Advances

One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media†

Ahmad Reza Moosavi-Zare,*a   Zhila Asgari,b   Abdolkarim Zare,*c   Mohammad Ali Zolfigol*b  and  Mohsen Shekouhyd  

* Corresponding authors

a Department of Chemistry, University of SayyedJamaleddinAsadabadi, Asadabad, Iran
E-mail: moosavizare@yahoo.com

b Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran

c Department of Chemistry, Payame Noor University, PO Box 19395-3697, Tehran, Iran

d Department of Chemistry, College of Science, Shiraz University, Shiraz, Iran

Abstract

Trityl chloride (TrCl or Ph3CCl) efficiently catalyzes the one-pot multi-component condensation of benzil with aldehydes, primary amines and ammonium acetate under neutral and solvent-free conditions to give 1,2,4,5-tetrasubstituted imidazoles in high to excellent yields and in short reaction times. Mechanistically, it is attractive that trityl chloride promotes the reaction by in situ generation of trityl carbocation (Ph3C+).

Graphical abstract: One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media

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Article information

DOI
https://doi.org/10.1039/C4RA10589C
Article type
Paper
Submitted
16 Sep 2014
Accepted
31 Oct 2014
First published
03 Nov 2014

RSC Adv., 2014,4, 60636-60639

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One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media

A. R. Moosavi-Zare, Z. Asgari, A. Zare, M. A. Zolfigol and M. Shekouhy, RSC Adv., 2014, 4, 60636 DOI: 10.1039/C4RA10589C

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