Issue 37, 2014
From the journal:

RSC Advances

A regioselective synthesis of the dephospho ditholene protected molybdopterin†

Igor V. Pimkov,a   Antoinette A. Peterson,a   David N. Vaccarelloa  and  Partha Basu*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
E-mail: basu@duq.edu

Abstract

The molybdopterin (MPT) is a complex molecule, made out of three distinctly different components. A retrosynthetic analysis provides a possible route for its synthesis that utilizes the coupling of a diamine with an osone analog. A regioselective condensation of the diamine with an osone affords the dephospho MPT, which has been characterized by NMR and IR spectroscopies, as well as high-resolution mass spectrometry.

Graphical abstract: A regioselective synthesis of the dephospho ditholene protected molybdopterin

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DOI
https://doi.org/10.1039/C4RA02786H
Article type
Paper
Submitted
29 Mar 2014
Accepted
11 Apr 2014
First published
11 Apr 2014

RSC Adv., 2014,4, 19072-19076

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A regioselective synthesis of the dephospho ditholene protected molybdopterin

I. V. Pimkov, A. A. Peterson, D. N. Vaccarello and P. Basu, RSC Adv., 2014, 4, 19072 DOI: 10.1039/C4RA02786H

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