Issue 77, 2014

Large negatively charged organic host molecules as inhibitors of endonuclease enzymes

Abstract

Three large negatively charged organic host molecules; β-cyclodextrin sulphate, para-sulphonato-calix[6]arene and para-sulphonato-calix[8]arene have been shown to be effective inhibitors of endonuclease in the low micromolar range, additionally para-sulphonato-calix[8]arene is a partial inhibitor of rhDNase I.

Graphical abstract: Large negatively charged organic host molecules as inhibitors of endonuclease enzymes

Supplementary files

Article information

Article type
Communication
Submitted
24 Jun 2014
Accepted
13 Aug 2014
First published
13 Aug 2014

Chem. Commun., 2014,50, 11404-11406

Author version available

Large negatively charged organic host molecules as inhibitors of endonuclease enzymes

Y. Tauran, C. Anjard, B. Kim, M. Rhimi and A. W. Coleman, Chem. Commun., 2014, 50, 11404 DOI: 10.1039/C4CC04805A

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