Issue 4, 2015
From the journal:

Biomaterials Science

Density gradients at hydrogel interfaces for enhanced cell penetration†

B. R. Simona,a   L. Hirt,a   L. Demkó,a   T. Zambelli,a   J. Vörös,a   M. Ehrbar*b  and  V. Milleret*b  

* Corresponding authors

a Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

b Laboratory for Cell and Tissue Engineering, Department of Obstetrics, University Hospital Zurich, Schmelzbergstr. 12, 8091 Zurich, Switzerland
E-mail: martin.ehrbar@usz.ch, vincent.milleret@usz.ch

Abstract

We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a promising strategy to progress in the creation of 3D tissue models.

Graphical abstract: Density gradients at hydrogel interfaces for enhanced cell penetration

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Article information

DOI
https://doi.org/10.1039/C4BM00416G
Article type
Communication
Submitted
02 Dec 2014
Accepted
26 Dec 2014
First published
14 Jan 2015

Biomater. Sci., 2015,3, 586-591

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Density gradients at hydrogel interfaces for enhanced cell penetration

B. R. Simona, L. Hirt, L. Demkó, T. Zambelli, J. Vörös, M. Ehrbar and V. Milleret, Biomater. Sci., 2015, 3, 586 DOI: 10.1039/C4BM00416G

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