Issue 38, 2013
From the journal:

Journal of Materials Chemistry B

Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs†

Lucía Casal-Dujat,‡a   Peter C. Griffiths,*b   Carlos Rodríguez-Abreu,c   Conxita Solans,d   Sarah Rogerse  and  Lluïsa Pérez-García*a  

* Corresponding authors

a Department of Pharmacology and Therapeutical Chemistry, Faculty of Pharmacy, and Institute of Nanoscience and Nanotechnology UB (IN2UB) Universitat de Barcelona, Spain
E-mail: mlperez@ub.edu

b Faculty of Engineering and Science, University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Kent, UK
E-mail: p.griffiths@gre.ac.uk

c International Iberian Nanotechnology Laboratory (INL), Braga, Portugal

d Department of Chemical and Biomolecular Nanotechnology, Institute for Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Científicas (IQAC/CSIC), Barcelona, Spain

e ISIS-STFC, Rutherford Appleton Laboratory, Harwell Oxford, Didcot OX11 0QX, UK

Abstract

Dicationic gemini surfactants based on bis-imidazolium salts with bromide counterions were synthesized and shown to self-assemble into micellar-type structures in aqueous solution. The solubilisation capability of these micelles for anionic drugs (valproate) indicates their great potential as drug nanocarriers. A range of physicochemical techniques including surface tension, fluorescence spectroscopy, small-angle neutron scattering (SANS) and pulsed-gradient spin-echo nuclear magnetic resonance (PGSE-NMR) have been used to determine the nanocarrier (micelle) structure and to quantify the interaction of the drug with the nanocarrier. The insights gained here, structural activity relationships such as hydrophobic dependence of the CMC and drug binding isotherms, will allow for a rational optimization of molecular structure.

Graphical abstract: Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs

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Article information

DOI
https://doi.org/10.1039/C3TB20289E
Article type
Paper
Submitted
02 Mar 2013
Accepted
04 Aug 2013
First published
16 Aug 2013

J. Mater. Chem. B, 2013,1, 4963-4971

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Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs

L. Casal-Dujat, P. C. Griffiths, C. Rodríguez-Abreu, C. Solans, S. Rogers and L. Pérez-García, J. Mater. Chem. B, 2013, 1, 4963 DOI: 10.1039/C3TB20289E

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