Issue 15, 2013
From the journal:

Journal of Materials Chemistry B

Copolythiophene-based water-gated organic field-effect transistors for biosensing†

Clément Suspène,a   Benoit Piro,*a   Steeve Reisberg,a   Minh-Chau Pham,a   Henrik Toss,b   Magnus Berggren,b   Abderrahim Yassarc  and  Gilles Horowitzc  

* Corresponding authors

a Univ. Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, 75205 Paris Cedex 13, France
E-mail: piro@univ-paris-diderot.fr
Tel: +33 157277223

b Department of Science and Technology (ITN), Linköpings Universitet, Campus Norrköping, Bredgatan 34, 601 74 Norrköping, Sweden
E-mail: magnus.berggren@liu.se
Tel: +46 (0)11 36 36 37

c LPICM, UMR CNRS 7647, Ecole Polytechnique, Route de Saclay, 91128 Palaiseau, France
E-mail: gilles.horowitz@polytechnique.edu
Tel: +33 169334354

Abstract

This paper reports on the sensing of proteins using water-gated organic field-effect transistors. As a proof-of-concept, streptavidin and avidin were used, with a biotinylated polymer as the active sensing material. The latter is a copolythiophene modified to graft biotin by peptidic coupling. After characterization of its structure, it was integrated as the channel material into transistors and its interactions with several proteins were investigated. Non-specific interactions were reduced when the polymer surface was pretreated with 1-octanol. In this case, human serum albumin had no effect on the transistor characteristics whereas avidin and streptavidin led to a decrease of the drain current.

Graphical abstract: Copolythiophene-based water-gated organic field-effect transistors for biosensing

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Article information

DOI
https://doi.org/10.1039/C3TB00525A
Article type
Paper
Submitted
12 Dec 2012
Accepted
13 Feb 2013
First published
13 Feb 2013

J. Mater. Chem. B, 2013,1, 2090-2097

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Copolythiophene-based water-gated organic field-effect transistors for biosensing

C. Suspène, B. Piro, S. Reisberg, M. Pham, H. Toss, M. Berggren, A. Yassar and G. Horowitz, J. Mater. Chem. B, 2013, 1, 2090 DOI: 10.1039/C3TB00525A

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