Issue 19, 2014

Cu(i)-catalyzed tandem decarboxylative/C–H activation coupling of cyclic diketones, proline and alkynes: synthesis of α-alkynylated pyrrolidine-oxyindoles

Abstract

An efficient ligand/base and oxidant-free copper(I) catalyzed intermolecular direct alkynylation (IDA) strategy has been developed for the synthesis of α-alkynylated pyrrolidine-oxindole derivatives using cyclic diketones, amino acids and alkynes via tandem decarboxylative/C–H activation and reductive-amination strategy.

Graphical abstract: Cu(i)-catalyzed tandem decarboxylative/C–H activation coupling of cyclic diketones, proline and alkynes: synthesis of α-alkynylated pyrrolidine-oxyindoles

Supplementary files

Article information

Article type
Communication
Submitted
03 Dec 2013
Accepted
14 Jan 2014
First published
15 Jan 2014

RSC Adv., 2014,4, 9412-9415

Cu(I)-catalyzed tandem decarboxylative/C–H activation coupling of cyclic diketones, proline and alkynes: synthesis of α-alkynylated pyrrolidine-oxyindoles

A. Kumar, M. Kumar, L. P. Gupta and M. K. Gupta, RSC Adv., 2014, 4, 9412 DOI: 10.1039/C3RA47238H

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