Issue 14, 2013

Ionic liquid-controlled conformational bias of tetracycline

Abstract

The conformational bias of tetracycline was investigated in a series of room-temperature 1-alkyl-3-methyl-imidazolium ionic liquids. Spectroscopic techniques such as circular dichroism, absorbance and fluorescence suggested that the switch between the extended and twisted conformation of tetracycline might be controlled by the aggregation state of the ionic liquids, which could be easily assessed by the resonance light scattering of homologous sets of ionic liquids with a common anion.

Graphical abstract: Ionic liquid-controlled conformational bias of tetracycline

Supplementary files

Article information

Article type
Paper
Submitted
05 Oct 2012
Accepted
21 Jan 2013
First published
23 Jan 2013

RSC Adv., 2013,3, 4582-4587

Ionic liquid-controlled conformational bias of tetracycline

L. P. Jameson and S. V. Dzyuba, RSC Adv., 2013, 3, 4582 DOI: 10.1039/C3RA22419H

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