Issue 10, 2013
From the journal:

Polymer Chemistry

Linear and hyperbranched phosphorylcholine based homopolymers for blood biocompatibility

Manraj Jawanda,a   Benjamin F. L. Lai,b   Jayachandran N. Kizhakkedathu,bc   Kazuhiko Ishiharad  and  Ravin Narain*a  

* Corresponding authors

a Department of Chemical and Materials Engineering, Alberta Glycomics Centre, University of Alberta, 116 St and 85 Ave, Edmonton, AB, Canada
E-mail: narain@ualberta.ca
Fax: +1 7804922881
Tel: +1 7804921736

b Department of Pathology and Laboratory Medicine, Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada

c Department of Chemistry, University of British Columbia, Vancouver, BC, Canada

d Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

Abstract

2-Methacryloyloxyethyl-phosphorylcholine (MPC) polymers are zwitterionic in character and are widely used in a range of biomedical devices. The availability of facile polymerization approaches has allowed the synthesis of well-defined MPC polymers, which are now used as delivery carriers for in vitro and in vivo applications. Although biocompatibility testing has extensively been performed on insoluble MPC-based materials, to the best of our knowledge, there are no reports on the hemocompatibility of soluble MPC polymers. Therefore, in this work, linear and hyperbranched MPC polymers of varying molecular weights are synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization. The polymers produced are studied for their blood compatibility, as a function of their molecular weights and structures (linear versus hyperbranched). The hemocompatibility studies including clot formation, complement and platelet activation, and hemolysis indicate that linear and hyperbranched MPC polymers are blood compatible. The remarkable difference in erythrocyte aggregation in the presence of linear and branched MPC polymers indicates the importance of the branched polymer architecture.

Graphical abstract: Linear and hyperbranched phosphorylcholine based homopolymers for blood biocompatibility

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Article information

DOI
https://doi.org/10.1039/C3PY00248A
Article type
Paper
Submitted
20 Feb 2013
Accepted
12 Mar 2013
First published
13 Mar 2013

Polym. Chem., 2013,4, 3140-3146

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Linear and hyperbranched phosphorylcholine based homopolymers for blood biocompatibility

M. Jawanda, B. F. L. Lai, J. N. Kizhakkedathu, K. Ishihara and R. Narain, Polym. Chem., 2013, 4, 3140 DOI: 10.1039/C3PY00248A

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