Issue 1, 2014

A sildenafil cocrystal based on acetylsalicylic acid exhibits an enhanced intrinsic dissolution rate

Abstract

Cocrystallisation of sildenafil with acetylsalicylic acid yields a 1 : 1 sildenafil–acetylsalicylic-acid cocrystal, as well as a 1 : 1 : 1 cocrystal salt involving a sildenafil cation, acetylsalicylate and salicylic acid. The 1 : 1 acetylsalicylic-acid-based cocrystal exhibits an enhanced intrinsic dissolution rate, as compared to sildenafil citrate (the active ingredient of Viagra®).

Graphical abstract: A sildenafil cocrystal based on acetylsalicylic acid exhibits an enhanced intrinsic dissolution rate

Supplementary files

Article information

Article type
Communication
Submitted
12 Apr 2013
Accepted
09 Oct 2013
First published
09 Oct 2013

CrystEngComm, 2014,16, 32-35

A sildenafil cocrystal based on acetylsalicylic acid exhibits an enhanced intrinsic dissolution rate

M. Žegarac, E. Lekšić, P. Šket, J. Plavec, M. Devčić Bogdanović, D. Bučar, M. Dumić and E. Meštrović, CrystEngComm, 2014, 16, 32 DOI: 10.1039/C3CE42013B

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