A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?

Elsa Alvarez; Alfonso Garcia Marquez; Thomas Devic; Nathalie Steunou; Christian Serre; Christian Bonhomme; Christel Gervais; Isabel Izquierdo-Barba; Maria Vallet-Regi; Danielle Laurencin; Francesco Mauri; Patricia Horcajada

doi:10.1039/C3CE41346B

A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?†

Elsa Alvarez,‡^a Alfonso Garcia Marquez,‡^a Thomas Devic,^a Nathalie Steunou,^a Christian Serre,^a Christian Bonhomme,^b Christel Gervais,^b Isabel Izquierdo-Barba,^cd Maria Vallet-Regi,^cd Danielle Laurencin,^e Francesco Mauri^f and Patricia Horcajada*^a

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* Corresponding authors

^a Institut Lavoisier, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 avenue des Etats-Unis, 78035 Versailles cedex, France
E-mail: patricia.horcajada-cortes@uvsq.fr
Fax: +33139254452
Tel: +33139254371

^b Laboratoire de Chimie de la Matière Condensée de Paris, Université Pierre et Marie Curie Paris 06 UMR CNRS 7574, Collège de France, 11 Place Marcelin Berthelot, Cedex 05, 75231 Paris, France

^c Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain

^d Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain

^e Institut Charles Gerhardt de Montpellier, UMR 5253, CNRS UM2 UM1 ENSCM, CC 1701 Université de Montpellier 2, Place E. Bataillon, cedex 5, 34095 Montpellier, France

^f Laboratoire de Minéralogie Cristallographie UMR CNRS 7590, Université Pierre et Marie Curie, Paris 06, France

Abstract

A novel, biocompatible, calcium-based coordination polymer was hydrothermally synthesized using as linker the bone antiresorptive bisphosphonate alendronate. Its structure was determined using single-crystal X-ray diffraction and characterized by chemical analysis, infrared spectroscopy (IR), X-ray powder diffraction (XRPD), solid state nuclear magnetic resonance (NMR) and thermogravimetric analysis (TGA). Its bioactivity was finally evaluated in vitro, revealing a very high stability towards simulated body fluid.

CrystEngComm

A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?†

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A biocompatible calcium bisphosphonate coordination polymer: towards a metal-linker synergistic therapeutic effect?

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