Issue 68, 2013
From the journal:

Chemical Communications

Detection of DNA induced gold nanoparticle aggregation with dark field imaging†

Tong Bu,ab   Tamotsu Zako,*b   Masahiro Fujitab  and  Mizuo Maeda*ab  

* Corresponding authors

a Department of Advanced Materials Science, School of Frontier Sciences, The University of Tokyo, Chiba 227-8561, Kashiwa, Japan

b Bioengineering Laboratory, RIKEN, Wako, Saitama 351-0198, Japan
E-mail: zako@riken.jp, mizuo@riken.jp

Abstract

Dark field imaging was employed to visualize and quantify complementary DNA-induced gold nanoparticle aggregation at the single-particle level, with a detection limit of 100 fM DNA, which allows the highly sensitive detection of single nucleotide polymorphisms (SNPs). Results suggested that the aggregation process is consistent with the cluster–cluster model.

Graphical abstract: Detection of DNA induced gold nanoparticle aggregation with dark field imaging

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Article information

DOI
https://doi.org/10.1039/C3CC44182B
Article type
Communication
Submitted
04 Jun 2013
Accepted
27 Jun 2013
First published
28 Jun 2013

Chem. Commun., 2013,49, 7531-7533

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Detection of DNA induced gold nanoparticle aggregation with dark field imaging

T. Bu, T. Zako, M. Fujita and M. Maeda, Chem. Commun., 2013, 49, 7531 DOI: 10.1039/C3CC44182B

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