Issue 52, 2013
From the journal:

Chemical Communications

Receptor conformational change induces fluoride binding despite competitive water binding†

Laurent Trembleau,*a   Tim A. D. Smithb  and  Mostafa H. Abdelrahmanc  

* Corresponding authors

a School of Natural and Computing Sciences, University of Aberdeen, Aberdeen AB24 3UE, UK
E-mail: l.trembleau@abdn.ac.uk

b School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

c Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, 71524 Assiut, Egypt

Abstract

Fluoride binding by artificial receptors in water remains a challenging task due to the high hydration enthalpy of this anion. A novel cationic boron-based tripodal receptor featuring three flexible ammonium-containing arms has been prepared. NMR spectroscopy studies show that the receptor is capable of binding selectively the fluoride anion with high affinity in acidic water.

Graphical abstract: Receptor conformational change induces fluoride binding despite competitive water binding

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Article information

DOI
https://doi.org/10.1039/C3CC43019G
Article type
Communication
Submitted
23 Apr 2013
Accepted
07 May 2013
First published
09 May 2013

Chem. Commun., 2013,49, 5850-5852

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Receptor conformational change induces fluoride binding despite competitive water binding

L. Trembleau, T. A. D. Smith and M. H. Abdelrahman, Chem. Commun., 2013, 49, 5850 DOI: 10.1039/C3CC43019G

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