A ratiometric naphthalimide sensor for live cell imaging of copper(I)

Cristina Satriano; Giuseppe Trusso Sfrazzetto; Maria Emanuela Amato; Francesco P. Ballistreri; Agata Copani; Maria Laura Giuffrida; Giuseppe Grasso; Andrea Pappalardo; Enrico Rizzarelli; Gaetano A. Tomaselli; Rosa Maria Toscano

doi:10.1039/C3CC42069H

A ratiometric naphthalimide sensor for live cell imaging of copper(i)†

Cristina Satriano,^a Giuseppe Trusso Sfrazzetto,^a Maria Emanuela Amato,^a Francesco P. Ballistreri,^a Agata Copani,^bc Maria Laura Giuffrida,^c Giuseppe Grasso,^a Andrea Pappalardo,^a Enrico Rizzarelli,*^a Gaetano A. Tomaselli*^a and Rosa Maria Toscano^a

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^a Department of Chemical Sciences, University of Catania, viale Andrea Doria, 6, 95125 Catania, Italy
E-mail: erizzarelli@unict.it, gtomaselli@unict.it
Fax: +39 095 337678
Tel: +39 095 7385070

^b Department of Drug Sciences, University of Catania, Viale Andrea Doria, Catania 95125, Italy

^c Institute of Biostructure and Bioimaging, National Research Council, Viale Andrea Doria, Catania 95125, Italy

Abstract

A new naphthalimide derivative bearing a tetrathia-azacrown for high affinity and selective binding to Cu⁺ was synthesised. Copper recognition properties in solution were evaluated using ¹H NMR and fluorescence spectroscopy. Live cell imaging by confocal microscopy highlighted the capabilities of the new sensor for the two-wavelength detection of intracellular monovalent copper in neuronal cells.

Chemical Communications

A ratiometric naphthalimide sensor for live cell imaging of copper(i)†

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A ratiometric naphthalimide sensor for live cell imaging of copper(I)

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