Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation

Kristy L. Peck; Heather S. Clewett; Jennifer C. Schmitt; Jason Shearer

doi:10.1039/C3CC40326B

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Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(i) site that is resistant to O₂ oxidation†

Kristy L. Peck,^a Heather S. Clewett,^a Jennifer C. Schmitt^a and Jason Shearer*^a

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^a Department of Chemistry, University of Nevada, Reno, USA
E-mail: shearer@unr.edu

Abstract

Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)₄ coordination environment, while reduction yields an O₂ inert linear bis-His Cu(I) centre.

This article is part of the themed collection: Medicinal Inorganic Chemistry

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Article information

DOI: https://doi.org/10.1039/C3CC40326B
Article type: Communication
Submitted: 15 Jan 2013
Accepted: 15 Apr 2013
First published: 23 Apr 2013

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Chem. Commun., 2013,49, 4797-4799

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Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O₂ oxidation

K. L. Peck, H. S. Clewett, J. C. Schmitt and J. Shearer, Chem. Commun., 2013, 49, 4797 DOI: 10.1039/C3CC40326B

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