A new method for the synthesis of N-t-butoxycarbonyl protected α-alkoxy amines from allylamines under neutral conditions
Abstract
Treatment of the Boc protected allylamines (4) with rhodium catalysts in the presence of alcohols produces N-Boc substituted α-alkoxy amines (5) in high yields, which can be used as a synthetic equivalents of activated imines having an easily deprotectable Boc group.