Issue 9, 2013
From the journal:

Journal of Materials Chemistry B

Microparticulate biomolecules by mild CaCO3 templating

Stephan Schmidtab  and  Dmitry Volodkin*b  

* Corresponding authors

a Max Planck Institut für Kolloid- und Grenzflächenforschung, Am Mühlenberg 1, Potsdam-Golm, Germany

b Fraunhofer IBMT, Am Mühlenberg 13, Potsdam-Golm, Germany
E-mail: Dmitry.Volodkin@ibmt.fraunhofer.de
Fax: +49 331 58187-399
Tel: +49 331-58187-327

Abstract

The article reviews recent studies on template assisted preparation of microparticles composed of proteins. The main line of development is focused on calcium carbonate (CaCO3) as microscopic sacrificial templates due to their biocompatibility and mild decomposition conditions that are mandatory in order to process fragile biomolecules. Consequently, we discuss several recent methods toward the preparation of protein particles via CaCO3 templating as well as synthesis of the templates. We emphasize how the physical and chemical properties of the template and proteins are exploited in order to obtain pure microparticulate protein therapeutics and multicomponent particle systems. We report on strategies that allow the tuning of material properties like catalytic activity, mechanical properties as well as capacity for a pharmaceutical payload. Finally, we give an overview on the perspectives of CaCO3 templated particles in biomedical applications.

Graphical abstract: Microparticulate biomolecules by mild CaCO3 templating

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Article information

DOI
https://doi.org/10.1039/C2TB00344A
Article type
Feature Article
Submitted
01 Nov 2012
Accepted
27 Nov 2012
First published
28 Nov 2012

J. Mater. Chem. B, 2013,1, 1210-1218

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Microparticulate biomolecules by mild CaCO3 templating

S. Schmidt and D. Volodkin, J. Mater. Chem. B, 2013, 1, 1210 DOI: 10.1039/C2TB00344A

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