Issue 8, 2013

Synthesis of fused triazolo[4,5-d]quinoline/chromene/thiochromene derivatives via palladium catalysis mediated by tetrabutylammonium iodide

Abstract

An expedient approach for the synthesis of various fused triazoles with varying functionality has been developed successfully via palladium catalysis in ligand free conditions. It was found that the additive TBAI greatly facilitates this palladium catalyzed cyclization to achieve the previously inaccessible fused triazolo[4,5-d]quinoline/chromene/thiochromene derivatives. This method provides a fast and simple access to obtain the fused triazoles in good to excellent yields. The synthesized compounds were screened with different cancer cell lines and the results has shown that compound 2a and 2f acts as inhibitors against specific non-small cell lung cancer cell line.

Graphical abstract: Synthesis of fused triazolo[4,5-d]quinoline/chromene/thiochromene derivatives via palladium catalysis mediated by tetrabutylammonium iodide

Supplementary files

Article information

Article type
Paper
Submitted
07 Nov 2012
Accepted
07 Dec 2012
First published
11 Dec 2012

RSC Adv., 2013,3, 2710-2719

Synthesis of fused triazolo[4,5-d]quinoline/chromene/thiochromene derivatives via palladium catalysis mediated by tetrabutylammonium iodide

C. Chen, C. Yang, W. Hu, J. Kishore Vandavasi, M. Chung and J. Wang, RSC Adv., 2013, 3, 2710 DOI: 10.1039/C2RA22799A

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