Issue 12, 2012

“Sulfolefin”: Highly modular mixed S/Olefinligands for enantioselective Rh-catalyzed 1,4-addition

Abstract

Reported is a single high yielding step approximation to mixed olefin/sulfinamide ligands enclosing a chiral sulfur atom as the sole chiral center. The synthetic design is validated by a rapid optimization of the substituent at the sulfinyl sulfur, and by the synthesis of an efficient, highly enantioselective catalyst for the Rh-catalyzed 1,4-addition of boronic acids to both, cyclic and acyclic olefins.

Graphical abstract: “Sulfolefin”: Highly modular mixed S/Olefin ligands for enantioselective Rh-catalyzed 1,4-addition

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov 2011
Accepted
21 Dec 2011
First published
22 Dec 2011

Org. Biomol. Chem., 2012,10, 2366-2368

“Sulfolefin”: Highly modular mixed S/Olefin ligands for enantioselective Rh-catalyzed 1,4-addition

N. Khiar, Á. Salvador, A. Chelouan, A. Alcudia and I. Fernández, Org. Biomol. Chem., 2012, 10, 2366 DOI: 10.1039/C2OB07132K

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