Issue 9, 2012
From the journal:

Nanoscale

Correlative light-ion microscopy for biological applications†

Sergio Bertazzo,a   Thomas von Erlach,a   Silvia Goldoni,a   Pelin L Çandarlıoğlua  and  Molly M Stevens*a  

* Corresponding authors

a Department of Materials, Department of Bioengineering and Institute of Biomedical Engineering, Imperial College London, London, UK
E-mail: m.stevens@imperial.ac.uk
Fax: +44 (0) 207 5946757
Tel: +44 (0) 207 5946804

Abstract

Here we report a new technique, Correlative Light-Ion Microscopy (CLIM), to correlate SEM-like micrographs with fluorescence images. This technique presents significant advantages over conventional methods in enabling topographical and biochemical information to be correlated with nanoscale resolution without destroying the fluorescence signal. We demonstrate the utility of CLIM for a variety of investigations of cell substrate interactions validating its potential to become a routine procedure in biomedical research.

Graphical abstract: Correlative light-ion microscopy for biological applications

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Article information

DOI
https://doi.org/10.1039/C2NR30431G
Article type
Communication
Submitted
23 Feb 2012
Accepted
27 Feb 2012
First published
06 Mar 2012

Nanoscale, 2012,4, 2851-2854

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Correlative light-ion microscopy for biological applications

S. Bertazzo, T. von Erlach, S. Goldoni, P. L. Çandarlıoğlu and M. M. Stevens, Nanoscale, 2012, 4, 2851 DOI: 10.1039/C2NR30431G

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