Issue 18, 2012
From the journal:

CrystEngComm

Rediscovering hydrogel-based double-diffusion systems for studying biomineralization†

Jason R. Dorvee,a   Adele L. Boskeyb  and  Lara A. Estroff*a  

* Corresponding authors

a Department of Material Science & Engineering, Cornell University, Ithaca, NY 14853, USA
E-mail: lae37@cornell.edu

b Weill Medical College, Cornell University and The Hospital for Special Surgery, New York, NY 10021, USA

Abstract

For those seeking to model biomineralization in vitro, hydrogels can serve as excellent models of the extracellular matrix (ECM) microenvironment. A major challenge posed in implementing such systems is the logistics involved, from fundamental engineering to experimental design. For the study of calcium phosphate (e.g., hydroxyapatite) formation, many researchers use hydrogel-based double-diffusion systems (DDSs). The various designs of these DDSs are seemingly as unique as their applications. In this Highlight, we present a survey of four distinct types of DDSs and evaluate them in the context of fundamental diffusion theory. Based upon this analysis, we present the design and evaluation of an optimized system. The techniques and framework for the evaluation and construction of a DDS presented here can be applied to any DDS that a researcher may want to implement for their particular studies of biomineralization.

Graphical abstract: Rediscovering hydrogel-based double-diffusion systems for studying biomineralization

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Article information

DOI
https://doi.org/10.1039/C2CE25289A
Article type
Highlight
Submitted
28 Feb 2012
Accepted
11 May 2012
First published
29 Jun 2012

CrystEngComm, 2012,14, 5681-5700

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Rediscovering hydrogel-based double-diffusion systems for studying biomineralization

J. R. Dorvee, A. L. Boskey and L. A. Estroff, CrystEngComm, 2012, 14, 5681 DOI: 10.1039/C2CE25289A

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