Issue 63, 2012
From the journal:

Chemical Communications

Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography†

Yunan Yang,‡a   Youhong Niu,‡b   Hao Hong,a   Haifan Wu,b   Yin Zhang,a   Jonathan W. Engle,a   Todd E. Barnhart,a   Jianfeng Cai*b  and  Weibo Cai*a  

* Corresponding authors

a Departments of Radiology and Medical Physics, University of Wisconsin - Madison, USA
E-mail: wcai@uwhealth.org

b Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, USA
E-mail: jianfengcai@usf.edu

Abstract

A γ-AApeptide-based tracer for positron emission tomography imaging of integrin αvβ3 is reported. Despite its shorter sequence and linear nature, this tracer had comparable integrin αvβ3 binding affinity to the cyclic arginine-glycine-aspartic acid peptide but significantly higher resistance to enzymatic degradation and better stability.

Graphical abstract: Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC33620K
Article type
Communication
Submitted
07 Mar 2012
Accepted
10 Jun 2012
First published
19 Jun 2012

Chem. Commun., 2012,48, 7850-7852

Permissions

Request permissions

Radiolabeled γ-AApeptides: a new class of tracers for positron emission tomography

Y. Yang, Y. Niu, H. Hong, H. Wu, Y. Zhang, J. W. Engle, T. E. Barnhart, J. Cai and W. Cai, Chem. Commun., 2012, 48, 7850 DOI: 10.1039/C2CC33620K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements