Issue 37, 2012

Monoacylglycerols as transmembrane Cl anion transporters

Abstract

We report that the amphiphilic natural product, monoacylglycerol 1, functions as a transmembrane Cl/NO3 anion transporter. The 1,2-diol group is crucial for the transport function since diacylglycerol and triacylglycerol analogs are not anion transporters. Furthermore, adding another hydrogen bond donor to the glycerol head-group and perfluorination of the acyl tail gave synthetic analogs with improved Cl membrane transport properties.

Graphical abstract: Monoacylglycerols as transmembrane Cl− anion transporters

Supplementary files

Article information

Article type
Communication
Submitted
29 Dec 2011
Accepted
02 Mar 2012
First published
29 Mar 2012

Chem. Commun., 2012,48, 4432-4434

Monoacylglycerols as transmembrane Cl anion transporters

S. Bahmanjah, N. Zhang and J. T. Davis, Chem. Commun., 2012, 48, 4432 DOI: 10.1039/C2CC18148G

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