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Development of hydrophilic photolabile hydroxyl protecting groups

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Abstract

Hydrophilic photolabile protecting groups (PPGs) for hydroxyl protection have been developed. The new PPGs are derived from 3-(dimethylamino)trityl (DMATr) by replacing the two methyl groups with two hydrophilic butyryl groups. The new PPG reagents can be readily prepared and installed. They are stable in the dark but can be removed cleanly and efficiently in aqueous environments upon irradiation with a UV lamp or sunlight.

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Authors and Affiliations

  1. Department of Chemistry, University of Alabama at Birmingham, 901 14th Street South, Birmingham, Alabama, United States

    Haishen Yang, Lei Zhou & Pengfei Wang

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  1. Haishen Yang
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  2. Lei Zhou
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  3. Pengfei Wang
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Correspondence to Pengfei Wang.

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Yang, H., Zhou, L. & Wang, P. Development of hydrophilic photolabile hydroxyl protecting groups. Photochem Photobiol Sci 11, 514–517 (2012). https://doi.org/10.1039/c1pp05281k

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  • DOI: https://doi.org/10.1039/c1pp05281k

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