Issue 11, 2011
From the journal:

Natural Product Reports

The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies

Andrew M. Harned*a  and  Kelly A. Volpa  

* Corresponding authors

a University of Minnesota, Department of Chemistry, 207 Pleasant Street SE, Minneapolis, MN, USA
E-mail: harned@umn.edu
Fax: (+1) 612-626-7541
Tel: (+1) 612-625-1036

Abstract

Covering: 1948 up to the end of 2010

The sorbicillinoids are a family of hexaketide metabolites that have been isolated from a variety of fungal sources, collected from both marine and terrestrial sources. Since 1948, the family has grown in size to include over 50 members, many of which have complex, highly oxygenated, bicyclic and tricyclic frameworks. In conjunction with their biological activity, the structural complexity of these structures has inspired several synthetic campaigns and has also led to controversy surrounding the biosynthetic pathway responsible for the natural production of these compounds. Through this review, we aim to give a historical perspective to each of these areas and hope to inspire new avenues of research for addressing the knowledge gaps that still exist.

Graphical abstract: The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies

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Article information

DOI
https://doi.org/10.1039/C1NP00039J
Article type
Review Article
Submitted
03 May 2011
First published
16 Sep 2011

Nat. Prod. Rep., 2011,28, 1790-1810

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The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies

A. M. Harned and K. A. Volp, Nat. Prod. Rep., 2011, 28, 1790 DOI: 10.1039/C1NP00039J

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