Issue 2, 2012

Regioselective C–H bond functionalizations of acridines using organozinc reagents

Abstract

Despite the recent advance in C–H bond functionalization chemistry, the C–H bonds in the acridine ring system, which is an important scaffold in medicinal and material science, have met with limited success, due, in part, to the lack of activated C–H bonds adjacent to the ring nitrogen atom. Herein, several protocols that can effect the regioselective arylation and alkylation of acridines at the C-4 and C-9 positions are described.

Graphical abstract: Regioselective C–H bond functionalizations of acridines using organozinc reagents

Supplementary files

Article information

Article type
Communication
Submitted
24 Oct 2011
Accepted
08 Nov 2011
First published
09 Nov 2011

Chem. Commun., 2012,48, 308-310

Regioselective C–H bond functionalizations of acridines using organozinc reagents

I. Hyodo, M. Tobisu and N. Chatani, Chem. Commun., 2012, 48, 308 DOI: 10.1039/C1CC16582H

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