Issue 38, 2011
From the journal:

Chemical Communications

Intrastrand locks increase duplex stability and base pairing selectivity†

Cora Prestinaria  and  Clemens Richert*a  

* Corresponding authors

a Institute for Organic Chemistry, University of Stuttgart, Pfaffenwaldring 55, 70565 Stuttgart, Germany
E-mail: lehrstuhl-2@oc.uni-stuttgart.de
Fax: 0049 (0)711/685-64311
Tel: 0049 (0)711/685-64321

Abstract

Oligodeoxynucleotide probes with disulfide locks between neighboring nucleobases show increases in melting point for duplexes with RNA target strands of up to 7.6 °C. The weakly pairing TT dimers are replaced with locked 2′-deoxy-5-(thioalkynyl)uridine residues via automated synthesis.

Graphical abstract: Intrastrand locks increase duplex stability and base pairing selectivity

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CC14008F
Article type
Communication
Submitted
05 Jul 2011
Accepted
06 Aug 2011
First published
24 Aug 2011

Chem. Commun., 2011,47, 10824-10826

Permissions

Request permissions

Intrastrand locks increase duplex stability and base pairing selectivity

C. Prestinari and C. Richert, Chem. Commun., 2011, 47, 10824 DOI: 10.1039/C1CC14008F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements