Issue 31, 2011
From the journal:

Chemical Communications

Direct amidation of azoles with formamidesvia metal-free C–H activation in the presence of tert-butyl perbenzoate†

Tao He,a   Hongji Li,a   Pinhua Lia  and  Lei Wang*ab  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P.R. China
E-mail: leiwang@chnu.edu.cn
Fax: +86 561 309 0518
Tel: +86 561 380 2069

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032, P.R. China

Abstract

A novel and simple method for the direct amidation of azoles with formamides has been developed. The reaction could occur smoothly in the presence of tert-butyl perbenzoate (TBPB) as an oxidant under metal- and base-free conditions. Direct dehydrogenative cross-coupling of formamides and azoles generated the corresponding products in good yields.

Graphical abstract: Direct amidation of azoles with formamidesvia metal-free C–H activation in the presence of tert-butyl perbenzoate

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Article information

DOI
https://doi.org/10.1039/C1CC13086B
Article type
Communication
Submitted
26 May 2011
Accepted
22 Jun 2011
First published
07 Jul 2011

Chem. Commun., 2011,47, 8946-8948

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Direct amidation of azoles with formamidesvia metal-free C–H activation in the presence of tert-butyl perbenzoate

T. He, H. Li, P. Li and L. Wang, Chem. Commun., 2011, 47, 8946 DOI: 10.1039/C1CC13086B

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