Issue 18, 2011

LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

Abstract

RNA nucleosides are often naturally modified into complex non-canonical structures with key biological functions. Here we report LC-MS quantification of the Ar(p) and Gr(p) 2′-ribosylated nucleosides in tRNA using deuterium labelled standards, and the first detection of Gr(p) in complex fungi.

Graphical abstract: LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2011
Accepted
13 Mar 2011
First published
29 Mar 2011

Chem. Commun., 2011,47, 5196-5198

LC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA

D. Pearson, A. Hienzsch, M. Wagner, D. Globisch, V. Reiter, D. Özden and T. Carell, Chem. Commun., 2011, 47, 5196 DOI: 10.1039/C1CC11011J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements