Issue 2, 2011
From the journal:

Organic & Biomolecular Chemistry

Targeting DNA base pair mismatch with artificial nucleobases. Advances and perspectives in triple helix strategy

Vincent Malnuit,a   Maria Ducaa  and  Rachid Benhida*a  

* Corresponding authors

a Laboratoire de Chimie des Molécules Bioactives et des Arômes, LCMBA, UMR 6001, Institut de Chimie de Nice, Université de Nice Sophia Antipolis, Parc Valrose, France
E-mail: benhida@unice.fr
Fax: +33-4-92076151
Tel: +33-4-92076174

Abstract

This review, divided into three sections, describes the contribution of the chemists’ community to the development and application of triple helix strategy by using artificial nucleic acids, particularly for the recognition of DNA sequences incorporating base pair inversions. Firstly, the development of nucleobases that recognise CG inversion is surveyed followed secondly by specific recognition of TA inverted base pair. Finally, we point out in the last section recent perspectives and applications, driven from knowledge in nucleic acids interactions, in the growing field of nanotechnology and supramolecular chemistry at the border area of physics, chemistry and molecular biology.

Graphical abstract: Targeting DNA base pair mismatch with artificial nucleobases. Advances and perspectives in triple helix strategy

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Article information

DOI
https://doi.org/10.1039/C0OB00418A
Article type
Perspective
Submitted
13 Jul 2010
Accepted
27 Sep 2010
First published
03 Nov 2010

Org. Biomol. Chem., 2011,9, 326-336

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Targeting DNA base pair mismatch with artificial nucleobases. Advances and perspectives in triple helix strategy

V. Malnuit, M. Duca and R. Benhida, Org. Biomol. Chem., 2011, 9, 326 DOI: 10.1039/C0OB00418A

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