Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile

Sankar K. Guchhait; Chetna Madaan

doi:10.1039/C0OB00022A

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Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile†

Sankar K. Guchhait*^a and Chetna Madaan^a

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* Corresponding authors

^a Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), S. A. S. Nagar (Mohali) - 160062, Punjab, India
E-mail: skguchhait@niper.ac.in
Fax: +91 (0)172 2214692
Tel: +91 (0)172 2214683

Abstract

With the development of a novel microwave-assisted one-pot tandem de-tert-butylation of tert-butyl amine in an Ugi-type multicomponent reaction product, tert-butyl isocyanide as a useful convertible isonitrile has been explored for the first time affording access to molecular diversity of pharmaceutically-important polycyclic N-fused imidazo-heterocycles.

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Supplementary files

General experimental procedure and characterization data for products PDF (154K)

Article information

DOI: https://doi.org/10.1039/C0OB00022A
Article type: Communication
Submitted: 20 Apr 2010
Accepted: 09 Jun 2010
First published: 24 Jun 2010

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Org. Biomol. Chem., 2010,8, 3631-3634

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Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile

S. K. Guchhait and C. Madaan, Org. Biomol. Chem., 2010, 8, 3631 DOI: 10.1039/C0OB00022A

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Organic & Biomolecular Chemistry

Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile†

Abstract

Supplementary files

Article information

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Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile

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