Issue 23, 2011

Biocompatible inorganic nanoparticles for [18F]-fluoride binding with applications in PET imaging

Abstract

A wide selection of insoluble nanoparticulate metal salts was screened for avid binding of [18F]-fluoride. Hydroxyapatite and aluminium hydroxide nanoparticles showed particularly avid and stable binding of [18F]-fluoride in various biological media. The in vivo behaviour of the [18F]-labelled hydroxyapatite and aluminium hydroxide particles was determined by PET-CT imaging in mice. [18F]-labelled hydroxyapatite was stable in circulation and when trapped in various tissues (lung embolisation, subcutaneous and intramuscular), but accumulation in liver via reticuloendothelial clearance was followed by gradual degradation and release of [18F]-fluoride (over a period of 4 h) which accumulated in bone. [18F]-labelled aluminium hydroxide was also cleared to liver and spleen but degraded slightly even without liver uptake (subcutanenous and intramuscular). Both materials have properties that are an attractive basis for the design of molecular targeted PET imaging agents labelled with 18F.

Graphical abstract: Biocompatible inorganic nanoparticles for [18F]-fluoride binding with applications in PET imaging

Supplementary files

Article information

Article type
Paper
Submitted
21 Nov 2010
Accepted
11 Feb 2011
First published
11 Mar 2011

Dalton Trans., 2011,40, 6226-6237

Biocompatible inorganic nanoparticles for [18F]-fluoride binding with applications in PET imaging

M. Jauregui-Osoro, P. A. Williamson, A. Glaria, K. Sunassee, P. Charoenphun, M. A. Green, G. E. D. Mullen and P. J. Blower, Dalton Trans., 2011, 40, 6226 DOI: 10.1039/C0DT01618G

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