Issue 23, 2011
From the journal:

Dalton Transactions

Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents

Flora L. Thorp-Greenwooda  and  Michael P. Coogan*a  

* Corresponding authors

a Department of Chemistry, Cardiff University, Cardiff, Cymru/Wales, UK
E-mail: cooganmp@cf.ac.uk
Fax: +44 (0)2920874030
Tel: +44 (0)2920874066

Abstract

This perspective focuses on complexes of radioactive metal ions applied in multimodal radio- and optical imaging. The application of metal ions in radioimaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) has advantages over lighter nuclei in terms of half-life, but there are particular issues related to their speciation (particularly leaching from complexes) and with the combination of certain ions with fluorescent systems. The basic coordination chemistry of the ions involved and issues relating to biological conditions and their compatibility with optical imaging techniques are reviewed, the current literature presented in context, and the prospect of exploiting the intrinsic luminescence of certain metal–ligand complexes is discussed.

Graphical abstract: Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents

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Article information

DOI
https://doi.org/10.1039/C0DT01398F
Article type
Perspective
Submitted
15 Oct 2010
Accepted
09 Dec 2010
First published
12 Jan 2011

Dalton Trans., 2011,40, 6129-6143

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Multimodal radio- (PET/SPECT) and fluorescence imaging agents based on metallo-radioisotopes: current applications and prospects for development of new agents

F. L. Thorp-Greenwood and M. P. Coogan, Dalton Trans., 2011, 40, 6129 DOI: 10.1039/C0DT01398F

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