Issue 2, 2011
From the journal:

Dalton Transactions

The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity†

Leticia Cubo,a   Trevor W. Hambley,b   Pablo J. Sanz Miguel,c   Amancio Carnero,d   Carmen Navarro-Ranningera  and  Adoración G. Quiroga*a  

* Corresponding authors

a Universidad Autónoma Madrid, Department of Inorganic Chemistry, Madrid, Spain
E-mail: adoracion.gomez@uam.es
Fax: +34 914974833
Tel: 34914974050

b School of Chemistry, The University of Sydney, NSW, Australia

c Fakultät Chemie, Technische Universität Dortmund, Dortmund, Germany

d Instituto de Biomedicina de Sevilla-IBIS, Sevilla, Spain

Abstract

The physical and biological properties have been determined for three Pt(IV) complexes with transamine ligands: trans,trans,trans-[PtCl2(OH)2(dimethylamine)(isopropylamine)] (1IV), trans,trans,trans-[PtCl2(OH)2(dimethylamine)(methylamine)] (2IV) and trans,trans,trans-[PtCl2(OH)2(isopropylamine)(methylamine)] (3IV). The crystal structures of 2IV and 3IV reveal substantial strain resulting from repulsion between the amine ligands and the chlorido and hydroxido ligands. All three complexes have reduction potentials in the range −666 to −770 mV, values usually associated with high resistance to reduction and low cytotoxicity. However, the complexes all demonstrate surprisingly high cytotoxicity with values and trends that closely follow those seen for the Pt(II) congeners of these complexes. These results are consistent with more rapid reduction of the Pt(IV) complexes than would be expected based on the reduction potentials, perhaps associated with the trans arrangement of the chlorido ligands.

Graphical abstract: The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity

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Article information

DOI
https://doi.org/10.1039/C0DT00565G
Article type
Paper
Submitted
28 May 2010
Accepted
27 Jul 2010
First published
08 Oct 2010

Dalton Trans., 2011,40, 344-347

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The preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity

L. Cubo, T. W. Hambley, P. J. Sanz Miguel, A. Carnero, C. Navarro-Ranninger and A. G. Quiroga, Dalton Trans., 2011, 40, 344 DOI: 10.1039/C0DT00565G

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